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High-consequence testing on primates, dogs, and rodents raises immense ethical red flags regarding pain management and confinement.

A prominent group of neuroscientists signed a declaration stating that non-human animals, including all mammals, birds, and many other creatures (like octopuses), possess the neuroanatomical substrates necessary to generate consciousness. High-consequence testing on primates

The scientific community addresses welfare through the principles of Replacement (using non-animal methods like computer models or in-vitro cultures), Reduction (using fewer animals per experiment), and Refinement (minimizing pain and distress through better husbandry and anesthesia). including all mammals