Absolutely not. The process is fundamentally lossless, meaning the cryptographic hash values of your rebuilt ISO match a clean original copy exactly.
. Converting back to ISO is often necessary for playing games on original hardware like a modded Wii or GameCube Step-by-Step Conversion Guide
Introduced by the team, RVZ is a modern, lossless compression format designed specifically for GameCube and Wii disc images.
In the conversion dialog box, you will be prompted to choose the output format. Select "ISO" (or ISO/RAW).