The "The PS3 application has likely crashed" error in RPCS3 can stem from various factors:
Always use Vulkan . The OpenGL renderer is legacy, significantly slower, and highly prone to crashes on modern graphic drivers. The "The PS3 application has likely crashed" error
Check for updates in Nvidia GeForce Experience or AMD Adrenalin. The "The PS3 application has likely crashed" error
: Remove the dev_flash directory from your main folder. The "The PS3 application has likely crashed" error
This fix has been confirmed by multiple users to resolve random crashes caused by "Vmin Shift Instability".