Keep your largest number in one corner (e.g., bottom-right). Directional Locking:

The original 2048, a 4x4 grid, rose to fame for its simple, addictive gameplay. Success demanded strategic planning and careful tile merging. However, the 16x16 variant takes this challenge to an extreme.

If the version you are playing has "hacked" features (like an Auto-Solver or Undo button):

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