Update 1.10.163 alters the core executable file ( Fallout4.exe ). The expands the game's scripting capabilities and relies on exact memory addresses within that file. Because the executable changed, F4SE and any mod relying on it became instantly incompatible, causing the game to crash on launch. How to Fix Your Modded Game
Minor structural fixes were implemented to prevent immediate crashes tied to navigating large mod load orders and interacting with the main menu interface. The Next-Gen Disruption: Why 1.10.163 Became Critical fallout 4 update 110 163